Valium (or diazepam) is one of the strongest tranquilizers. Tranquilizers are drugs that are prescribed to eliminate anxiety, feelings of fear and heightened arousal. They have little effect on the state of the cardiovascular and respiratory systems, and also do not cause serious adverse reactions from the central nervous system (with proper application).
Instructions for use and dosage of “Diazepam”
“Diazepam” in tableted form is taken regardless of food intake. Instructions for use and dosage are individual and depend on the type of pathology and severity of the patient’s condition. When treating anxiety disorders, 2.5-10 mg of the drug is prescribed 2-4 times a day. With neuroses – 5-10 mg 2-3 times a day. Children older than 3 years are prescribed minimal doses, usually 2.5 mg. The course of medication is minimal. The solution of “Diazepam” is injected intramuscularly and intravenously with a stream or drip. As a rule, injections are administered three times a day for 1 ampoule.
“Diazepam” enhances the effect of ethanol, antidepressants, sedatives, antipsychotic drugs. Antacids reduce the absorption of “Diazepam”, MAO inhibitors (microsomal oxidation) enhance its effect. Simultaneous reception of this drug with other groups of psychotropic drugs reduces its effect.
- sedative with psychomotor excitation, in dermatological practice with itching dermatoses;
- Anxiolytic agent in acute anxiety-phobic and anxiety-depressive states, alcoholic psychoses with abstinence phenomena;
- muscle relaxing and anticonvulsant with muscular spasms of central origin in neurodegenerative diseases, including spinal cord injuries, lumbago, cervical radiculitis.
- Preparation for surgical interventions and diagnostic procedures.
Metabolism of diazepam occurs in the liver cells. One of its metabolites (nordiazepam) also has a depressing effect at the level of the central nervous system (CNS). Since nordiazepam is excreted from the body very slowly (for more than 4 days), repeated use of diazepam may cause an increase in its clinical effects and lead to the development of symptoms of intoxication. Diazepam excretion period from the body Approximately 70% of the drug injected into the body is excreted through the kidneys along with the urine. A small amount of diazepam is released into the gastrointestinal tract. The rate of excretion of the drug does not depend on the route of its introduction into the body, but is determined only by the functional state of the kidneys of the patient. The half-life (the time during which the concentration of active substance in the blood plasma is halved) for diazepam is about 48 hours. At the same time, for the above-mentioned metabolite (nordiazepam), the elimination half-life is about 96 hours, which can cause the effects of the drug to persist for several days after the end of its use.